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Moreover, it reduced the recovery time, prevented infection in the wound area, and prevented redness and itching. In these studies, Aloe vera was more effective than petroleum jelly gauze dressing, silver sulfadiazine 1% ointment, and framycetin cream. Five studies investigated burn wound healing. Aloe vera is considered as the traditional therapy for burns. 18 Most of the studies were conducted on burn wounds. 17 Aloe vera is highly suitable for wound dressings.
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#SOURCE UNPACK CRACKED SKIN#
16 Topical application of Aloe vera to prevent ulcers and enhance the healing process of dermal injuries (e.g., burns, frostbite, skin infections, surgical wounds, inflammation, herpes ulcers, diabetic foot ulcers, pressure sores, and chronic wounds) has been reported. Wound healing and preventive effects of Aloe vera have been reported in several studies. These articles were removed and eventually, 23 articles were evaluated.
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In total, 57 articles were identified out of which 16 were conducted on animals, 2 lacked access to the full text, 10 lacked transparency of statistical results, and 6 had a sample size less than 30 cases. The present study aimed to review research studies on this topic. 6Ĭonsidering the availability of several clinical trials on the effect of Aloe vera on the prevention and healing of skin wounds, as well as its popularity among people and widespread use in the cosmetic industry, Vera is known for its anti-tumor, anti-inflammatory, skin protection, anti-diabetic, anti-bacterial, anti-viral, antiseptic, and wound healing properties. Studies have shown the positive effects of Aloe vera to treat wounds such as psoriasis, mouth sores, ulcers, diabetes, herpes, bedsores, and burn Mucopolysaccharides along with amino acids and zinc present in Aloe vera can lead to skin integrity, moisture retention, erythema reduction, and helps to prevent skin ulcers. Studies have shown that the gel can increase the flexibility and reduce the fragility of the skin since 99% of the gel is water. Of collagen in wounds but also change the composition of collagen, increase collagen cross-linking and thereby promote wound healing. Aloe vera gel can not only increase the amount GlucomannanĪffects fibroblast growth factor receptors and stimulates their activity and proliferation, which in turn increases the production of collagen. 10 Its regenerative properties are due to the compound glucomannan, which is rich with polysaccharides like mannose. 8, 9 It also enhances the immune system and the synthesis of cytokines.Īloe vera is effective in inhibiting inflammatory reactions by the inhibition of IL-6 and IL-8, the reduction of leukocyte adhesion, an increase of IL-10 levels, and decrease of TNF alpha 3, 7 Magnesium lactate available in the gel can prevent the production of histamine that causes Studies and studies conducted on living organisms have shown that Aloe vera can inhibit thromboxane (an inhibitor of wound healing), improve the wound healing process,Īnd reduce inflammation. 4 So far,ħ5 known compounds have been identified in Aloe vera, including 20 minerals, 20 amino acids, vitamins, and water. The Egyptian queens Nefertiti and Cleopatra used Aloe vera as part of their regular beauty regime. To Cactus and is an herbaceous and perennial plant with thick, fleshy and long leaves. It belongs to the Liliaceae family it is similar 3 Aloe vera is an indigenous plant from tropical Madagascar, Saudi Arabia, and Iran. It also has been used for centuries as a traditional medicine for various diseasesĪnd skin lesions. Studies on Aloe vera have been conducted and shown to be effective in the prevention and healing of skin wounds.Īloe vera is a medicinal plant traditionally used since 1500 BC in many countries such as Greece, China, and Mexico. The second phase involves the removal of dead tissue and the third phase of proliferation includes epithelial regeneration and fibrous tissue formation. The first phase is inflammation, congestion,Īnd leukocyte infiltration. 1 Wound healing is a dynamic process that takes place in three phases. Skin lesions are caused due to different reasons such as burns,Īrterial diseases, surgery, and trauma. The process of wound healing is a complex biological process and promotion of tissue recovery is the main objective of medical interventions.